《Effect of yerba mate (Ilex paraguariensis)
extract on the metabolism of diabetic rats》
《马黛茶提取物对糖尿病大鼠代谢的影响》
作者：
Débora Santos Rocha, Lucas Casagrande等
研究单位：
Federal University of Rio Grande do Sul
巴西南里奥格兰德联邦大学生理学系
研究目的：
The relationship between metabolic
disturbances and clinical events
related to diabetes is well known.
Yerba mate has presented a potential
use as preventive and therapeutic
agent on diabetes. The aim of this
study was to evaluate the effect
of yerba mate on different tissues
of diabetic rats, focusing
on energetic metabolism.
Diabetes was induced by streptozotocin,
followed by daily yerba mate treatment.
After 30 days, the animals were euthanized
to evaluate metabolic parameters on liver,
adipose tissue, muscle and serum.
The results showed mate treatment
promoted a decrease in retroperitoneal
adipose tissue in healthy animals.
Muscle weight returned to control
levels in diabetic rats treated with mate.
There was improvement on serum glucose,
creatinine, urea and total protein
levels associated with mate treatment.
Muscle parameters,
such as glucose uptake and carbon
dioxide production,
were improved by mate treatment
to control levels.
The results evidenced the
beneficial actions mate can have
on metabolic disturbances of diabetes.
众所周知代谢紊乱
与糖尿病存在临床事件之间的关系。
马黛茶具有作为糖尿病
预防和治疗药物的潜在用途。
本研究旨在评价马黛茶对
糖尿病大鼠不同组织的影响，
重点关注能量代谢。
糖尿病是由链脲佐菌素诱导的，
随后是每日一次的马黛茶饮用。
30天后处理动物，评估肝脏、
脂肪组织、肌肉和血清的代谢参数。
结果表明，马黛茶促进了健康
动物腹膜后脂肪组织的减少。
在接受马黛茶治疗的糖尿病大鼠中，
肌肉重量恢复至对照水平。
与马黛茶治疗相关的血糖、肌酐、
尿素和总蛋白水平有所改善。
通过交叉处理改善肌肉参数，
如葡萄糖摄取和二氧化碳生成，
以控制水平。结果证明了马黛茶
对糖尿病代谢紊乱的有益作用。
Yerba mate (Ilex paraguariensis)
is a native species from
South America.
Its leaves and stems are used to
prepare a tea-like beverage
widely consumed by the local population.
Studies have shown that yerba mate
has potential properties, performing
improvements on oxidative imbalance
and lipid metabolism
. These properties are mainly
related to its bioactive fractions,
represented by methylxanthines,
saponins and polyphenols.
Large quantities of phenolic
compounds been found in yerba mate
. This fraction has been presenting
protective effect against oxidative
damage to lipids and DNA [1].
The lipid peroxidation, particularly in
blood vessels, is mitigated by
treatment with mate
in face of high-fatdiet .
马黛茶(Ilex paraguariensis)
是一种原产于南美洲的植物。
它的叶和茎被用来制备茶状饮料，
被当地居民广泛消费。
研究表明，马黛茶具有潜在的特性，
可改善氧化失衡和脂质代谢.
这些性质主要与其生物活性成分有关，
以甲基黄嘌呤、皂苷和多酚为代表。
在耶尔巴马泰中发现了大量的酚类化合物.
该级分对脂质和DNA的氧化损伤
具有保护作用.面对高脂肪饮食，
通过饮用马黛茶可以减轻脂质过氧化，
特别是血管中的脂质过氧化.
According to the
World Health Organization (WHO),
the overall prevalence
of diabetes mellitus was estimated
in 9% in 2014 and rising
. So, faced the alarming prevalence
of diabetes and the potential
use of I. paraguariensis’ extract
as additional therapy. The aim of this
study was to evaluate the muscle
and liver metabolism of diabetic rats
after treatment with yerba mate.
根据世界卫生组织(世卫组织)的数据，
2014年糖尿病的总前驱症
状估计为9%，并且正在上升.
面临着令人担忧的糖尿病患病率和马黛茶提取物
作为附加疗法的潜在用途。
本研究的目的是评估糖尿病大鼠
接受马黛茶治疗后的肌肉和肝脏代谢。
Male Wistar rats (8 weeks old)
were divided into four groups:
control (C), control treated
with mate (CM),
diabetes (D) and diabetes