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PLAYADITO丨马黛茶提取物对糖尿病代谢的影响

日期: 2023-03-31
浏览次数: 0

《Effect of yerba mate (Ilex paraguariensis)

extract on the metabolism of diabetic rats》

《马黛茶提取物对糖尿病大鼠代谢的影响》

作者:

Débora Santos Rocha, Lucas Casagrande等

研究单位:

Federal University of Rio Grande do Sul

巴西南里奥格兰德联邦大学生理学系

研究目的:

The relationship between metabolic

disturbances and clinical events

related to diabetes is well known.

Yerba mate has presented a potential

use as preventive and therapeutic

agent on diabetes. The aim of this

study was to evaluate the effect

of yerba mate on different tissues

of diabetic rats, focusing

on energetic metabolism.

PLAYADITO丨马黛茶提取物对糖尿病代谢的影响


Diabetes was induced by streptozotocin,

followed by daily yerba mate treatment.

After 30 days, the animals were euthanized

to evaluate metabolic parameters on liver,

adipose tissue, muscle and serum.

The results showed mate treatment

promoted a decrease in retroperitoneal

adipose tissue in healthy animals.

Muscle weight returned to control

levels in diabetic rats treated with mate.

There was improvement on serum glucose,

creatinine, urea and total protein

levels associated with mate treatment.

Muscle parameters,

such as glucose uptake and carbon

dioxide production,

were improved by mate treatment

to control levels.

The results evidenced the

beneficial actions mate can have

on metabolic disturbances of diabetes.

PLAYADITO丨马黛茶提取物对糖尿病代谢的影响


众所周知代谢紊乱

与糖尿病存在临床事件之间的关系。

马黛茶具有作为糖尿病

预防和治疗药物的潜在用途。

本研究旨在评价马黛茶对

糖尿病大鼠不同组织的影响,

重点关注能量代谢。

糖尿病是由链脲佐菌素诱导的,

随后是每日一次的马黛茶饮用。

30天后处理动物,评估肝脏、

脂肪组织、肌肉和血清的代谢参数。

结果表明,马黛茶促进了健康

动物腹膜后脂肪组织的减少。

在接受马黛茶治疗的糖尿病大鼠中,

肌肉重量恢复至对照水平。

与马黛茶治疗相关的血糖、肌酐、

尿素和总蛋白水平有所改善。

通过交叉处理改善肌肉参数,

如葡萄糖摄取和二氧化碳生成,

以控制水平。结果证明了马黛茶

对糖尿病代谢紊乱的有益作用。

PLAYADITO丨马黛茶提取物对糖尿病代谢的影响


Yerba mate (Ilex paraguariensis)

is a native species from

South America.

Its leaves and stems are used to

prepare a tea-like beverage

widely consumed by the local population.

Studies have shown that yerba mate

has potential properties, performing

improvements on oxidative imbalance

and lipid metabolism

. These properties are mainly

related to its bioactive fractions,

represented by methylxanthines,

saponins and polyphenols.

Large quantities of phenolic

compounds been found in yerba mate

. This fraction has been presenting

protective effect against oxidative

damage to lipids and DNA [1].

The lipid peroxidation, particularly in

blood vessels, is mitigated by

treatment with mate

in face of high-fatdiet .

马黛茶(Ilex paraguariensis)

PLAYADITO丨马黛茶提取物对糖尿病代谢的影响


是一种原产于南美洲的植物。

它的叶和茎被用来制备茶状饮料,

被当地居民广泛消费。

研究表明,马黛茶具有潜在的特性,

可改善氧化失衡和脂质代谢.

这些性质主要与其生物活性成分有关,

以甲基黄嘌呤、皂苷和多酚为代表。

在耶尔巴马泰中发现了大量的酚类化合物.

该级分对脂质和DNA的氧化损伤

具有保护作用.面对高脂肪饮食,

通过饮用马黛茶可以减轻脂质过氧化,

特别是血管中的脂质过氧化.

PLAYADITO丨马黛茶提取物对糖尿病代谢的影响


According to the

World Health Organization (WHO),

the overall prevalence

of diabetes mellitus was estimated

in 9% in 2014 and rising

. So, faced the alarming prevalence

of diabetes and the potential

use of I. paraguariensis’ extract

as additional therapy. The aim of this

study was to evaluate the muscle

and liver metabolism of diabetic rats

after treatment with yerba mate.

PLAYADITO丨马黛茶提取物对糖尿病代谢的影响


根据世界卫生组织(世卫组织)的数据,

2014年糖尿病的总前驱症

状估计为9%,并且正在上升.

面临着令人担忧的糖尿病患病率和马黛茶提取物

作为附加疗法的潜在用途。

本研究的目的是评估糖尿病大鼠

接受马黛茶治疗后的肌肉和肝脏代谢。

PLAYADITO丨马黛茶提取物对糖尿病代谢的影响


Male Wistar rats (8 weeks old)

were divided into four groups:

control (C), control treated

with mate (CM),

diabetes (D) and diabetes

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